Specificity in Tyrosine Kinase-Mediated Signal Transduction

Prof. John E. Ladbury - Department of Biochemistry and Molecular Biology The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

In my group we explore the structural, biophysical, and cellular outcomes of protein complex formation at membrane-bound receptors. We use Microscale Thermophoresis (MST) in addition to other methods including isothermal titration calorimetry and surface plasmon resonance and find a good agreement between the methods. We are very pleased with the low material consumption, short measurement times and broad application range of MST.

Prof. John E. Ladbury