Signal Transduction – Targeting Rho family GTPases

Yi Zheng, PhD, Director, Division of Experimental Hematology and Cancer Biology; Katherine Stewart Waters Endowed Chair, University of Cincinnati College of Medicine, USA

 "We are studying the molecular mechanisms of signal transduction processes involving Rho GTPases and are developing small molecule inhibitors and other strategies that interfere with specific Rho protein functions in leukemia, lymphoma and lung cancer We are very enthusiastic about MST as it quickly enabled us to measure protein:protein and protein:small molecule interactions that have been difficult to detect and quantify with standard biomolecule interaction technologies in the past years. MST provides us with a unique tool to validate the lead inhibitors that bind to specific sites of Rho GTPases or their regulators/effectors "

Prof. Yi Zheng