Sanofi R&D Drug Discovery

Dr. Alexey Rak, Head of Structural Biology & Biophysics, Sanofi R&D, France

 "We routinely assess interaction affinity for both small molecule and biologics projects, with NanoTemper Technologies' Microscale Thermophoresis being the most recent addition to the pool of instruments we use to carry out these measurements. It has proved a valuable tool for characterising small molecule-protein and protein-protein interactions, as well as for the study of protein aggregation concentration determination. There is very good agreement with other technologies such as Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC), and we are particularly appreciative of this new technology because of the extremely low protein consumption and relatively short time required for the assay setup. NanoTemper customer support has been a key factor in enabling us to familiarise ourselves with the new technology. We would like to deploy increasing numbers of applications based on MST technologies and continue to interact with NanoTemper Technologies Company, a dynamic, scientifically driven company." 

Dr. Alexey Rak, 

Head of Structural Biology & Biophysics - BBC, SDI Paris/LGCR, Sanofi R&D, France. 

Dr. Alexey Rak