Epigenetics – Histone Code

Prof. Dr. Axel Imhof, Head of the Chromatin Modification Group, Adolf Butenand Institute, LMU, Munich, Germany

We are interested in the basic mechanisms in epigenetics which define and maintain the histone code and are using MST  to measure the binding of “reader”-proteins to modified histone peptides as well as the activity and inhibition of “writer” enzymes including kinases, demethylases and methylases.

The new MST technology is easy to use and a good alternative to our standard enzymatic assays which are radioactive and measure endpoints only. It allows us to easily measure affinities for protein-peptide interactions in solution”

Prof. Dr. Axel Imhof