Chromatin Dynamics and Nuclear Architecture

Prof. Dr. Gernot Längst, Biochemistry III, University of Regensburg, Germany

 "Our lab focuses on the mechanisms and organization of DNA packaging inside the cell nucleus. We study the biochemical properties of molecular machines, the chromatin remodelers that regulate DNA accessibility and switch between 'on' and 'off' states of genes. We are using MST for studying the activity of chromatin remodeling enzymes and to quantify their affinities towards DNA, RNA and other proteins. MST is a big step forward towards quantitative biochemistry. MST is simple to use and was quickly established in our lab. It is a good alternative to the traditional electrophoretic mobility shift assays".

Prof Gernot Längst